Conversations From Calais aims to re-humanise those affected by the refugee crisis by using public space to share conversations volunteers have had with migrants met in Calais. It is a way of bearing witness for the thousands of displaced people stuck in Calais and trying to reach the UK, whose voices are so often silenced or ignored.What does mediation mean/do for/in visual and culture studies? This is the question that we asked ourselves throughout the 4Cs, more particularly over the mediation labs and the workshops. In this handbook, we have gathered essays from curators and thinkers as well as the materials produced during the mediation activities of the 4Cs. Composed as much of theories as of practical examples, the handbook aims to provide a critical reflection on the transforming potential of mediation.